Preparation, characterization, and in vitro release of ketoprofen loaded alginate microspheres

Abstract

Objective: Ketoprofen is a nonsteroidal anti-inflammatory drug which could benefit if fabricated in a sustained delivery system. This work aims to develop the sustained release delivery system for ketoprofen using natural polymers. Methods: Alginate microspheres were prepared employing crosslinking method employing calcium chloride. The formation and compatibility of microspheres was confirmed by FT-IR. The formed microspheres were evaluated for percentage yield, drug content, drug loading, and encapsulation efficiency. In vitro release studies were carried out in phosphate buffer (pH 7.4). Results: FT-IR spectra exhibited the successful compatible encapsulation of ketoprofen in alginate microsphers. The formed microspheres exhibited good drug loading and encapsulation efficiency. The drug release was sustained over a period of 8 hours. There was a better release profile in phosphate buffer in formulations containing 3:1 polymer to drug ratio. Conclusion: It was feasible to prepare alginate-based microspheres capable of sustaining ketoprofen release over an extended period of time.